Research of changes in the level of endothelin-1 in experimental diabetic retinopathy. comparison of methods of correction

Diabetic retinopathy (DR) according to the WHO is main cause of decreased vision and blindness due diabetes.
 The aim study: compare effectiveness correction vasoconstriction in experimental diabetic under influence different methods correction.
 Our results indicate a violation functional state blood vessels on 30th day with subsequent progression pathological changes 60th 180th study, as evidenced by significant increase endothelin-1 2nd group (p <0.001), most pronounced 3rd stage.In analysis data №3 it was found that conditions hypoglycemic agents has positive effect, but does not allow significantly correct pathologically increased levels endothelin-1, which indicates need for additional tools other than hyperglycemia.The 4 involvement donor nitric oxide aflibercept corrects level studied marker, effect observed experiment, normative values can be achieved. It 5th group, simulated condition performed reducing hyperglycemia, introduction bromfenac gives results, less 4th where L-arginine solution added complex correction. .It rats 6, administration aflibercept, L-carnitine have proposed method compared previous methods, stage continues recover following stages reach values. obtained suggest selected 7, includes reduction citicoline effective normalizing vascular tone structural endothelium.